ConStrains identifies microbial strains in metagenomic datasets
نویسندگان
چکیده
منابع مشابه
Accurate Reconstruction of Microbial Strains from Metagenomic
Exploring the genetic diversity of microbes within the environment through metagenomic 5 sequencing first requires classifying these reads into taxonomic groups. Current methods compare these 6 sequencing data with existing biased and limited reference databases. Several recent evaluation studies 7 demonstrate that current methods either lack sufficient sensitivity for species-level assignments...
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The Human Pan-Microbe Communities (HPMC) database (http://www.hpmcd.org/) provides a manually curated, searchable, metagenomic resource to facilitate investigation of human gastrointestinal microbiota. Over the past decade, the application of metagenome sequencing to elucidate the microbial composition and functional capacity present in the human microbiome has revolutionized many concepts in o...
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BACKGROUND Soil is among the most diverse and complex environments in the world. Soil microorganisms play an essential role in biogeochemical cycles and affect plant growth and crop production. However, our knowledge of the relationship between species-assemblies and soil ecosystem processes is still very limited. The aim of this study was to generate a comprehensive metagenomic survey to evalu...
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Several PCR methods have recently been developed to identify fecal contamination in surface waters. In all cases, researchers have relied on one gene or one microorganism for selection of host-specific markers. Here we describe the application of a genome fragment enrichment (GFE) method to identify host-specific genetic markers from fecal microbial community DNA. As a proof of concept, bovine ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2015
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.3319